Hello David,
would like to give you some feedback regarding IE10 and CKEditor.
CTRL+S plugin works only if the mouse pointer is located over the toolbar or moved to the toolbar just after the CTRL+S is pressed (rather strange behavior)…
It was the same in IE8, but I wanted to wait, till the IE10 is available for our end users so I could test and issue this to you for both browsers.
Chrome and FF: everything works properly and users like it!